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Sacox - The Gold Standard
Choosing the right coccidiostat for your flock is key to ensuring optimal production performance. Sacox offers poultry producers:
- Zero-day withdrawal
- Excellent coccidiosis control
- Precision dosing and homogenous mixing thanks to its unique microgranulation formulation
Is coccidiosis costing your business?
Coccidiosis is caused by protozoan parasites which are impossible to irradicate, making it one of the most widespread and costly poultry diseases.
In current production systems it is vital that coccidiosis control methods are applied to reduce the infection pressure and prevent considerable economic losses.
Biosecurity alone is not enough
Thorough disinfection is an important first step in controlling the disease, but the extreme resistance of the sporulated oocysts (the infective stage of Eimeria parasites) makes their eradication impossible.
Some molecules have proven efficacy against Eimeria oocysts and can be used to significantly reduce the number of oocysts present at the start of a new flock.
However, it is widely accepted that preventative chemotherapy or using coccidiostats is necessary to sufficiently control coccidiosis. Modern poultry production would not be possible at such high levels without coccidiosis control.
Ionophore mode of action
Ionophores interact with ion transportation (hence their name which comes from the Greek 'ion phoros' or ion carrier). Ionophores transport ions across hydrophobic membranes, and in this case the parasite wall (Figure 1). The higher concentration of ions on the inside of the parasite causes an increase in water uptake through osmosis which results in swelling and eventually bursting of the cell.
Figure 1. Illustration of ion transport by ionophores. In poultry, ionophores act as a carriers to pass ions through the cell membrane.
What makes ionophores the superior choice of coccidiostat is that they can kill Eimeria species earlier in their lifecycle, during the motile stages (sporozoites and merozoites).
To be effective, the ionophore must be present in the intestinal lumen at the same time as these motile stages. Birds kept on litter constantly ingest oocysts, so it is important that ionophore programs are not interrupted.
Slow selection for resistance
The slow selection for resistance is another key benefit of ionophores. Due to the inherent characteristic of 'ionophore leakage', some parasites escape the effect of the product. The competitive advantage for the resistant parasites is less pronounced and so the shift to an increasingly resistant parasite population is a lot slower compared to synthetic compounds (Figure 2).
Figure 2. Resistant and sensitive parasite strain population following treatment with ionophore and synthetic coccidiosis control products. In contrast to synthetic products, ionophores will allow some parasite multiplication. This will result in higher shedding of sensitive parasites which will compete with the resistant parasites. As a result, the house will not be flooded by resistant strains.
Salinomycin
Huvepharma is the only company marketing salinomycin in Europe and the US.
In Europe our salinomycin product is called Sacox® and in the US it is called Bio-Cox®.
As a result of the regular sensitivity testing that we carry out on our coccidiostats, we can perform meta-analysis on data collected over several years to compare the efficacy of different coccidiostats. In one such meta-analysis, salinomycin was compared to narasin. The meta-analysis showed that birds fed diets containing Sacox / Bio-Cox had a higher average daily gain, a higher average daily feed intake, and a better conversion rate.
To add Sacox / Bio-Cox to your coccidiostat rotation, fill in the form below or contact your local Huvepharma representative.
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Huvepharma® is a fast-growing, global pharmaceutical company with a focus on developing, manufacturing and marketing human and animal health and nutrition products.
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