REGION:
Products
- Abantel® 260 mg
- Abantel® 520 mg
- Allergovet 10% solution for injection
- Apramycin 200 mg solution for injection
- Apramycin water-soluble powder
- Biomix® vitamin and mineral premix for pigs
- Biomix® vitamin and mineral premix for ruminants
- Biovit® 10% premix
- Bulmectin 0.2% premix
- Diar-stop forte
- Gentamicin 4% solution for injection
- Gentamicin 10% solution for injection
- Oxytetracycline 10% solution for injection
- Oxytocin solution for injection
- Pandex® 1% solution for injection
- Pharmasin®, Tylovet® B-50, B-200 solution for injection
- Pharmasin®, Tylovet® forte water-soluble for pigs
- Pharmasin®, Tylovet® forte water-soluble for poultry
- Pharmasin®, Tylovet® pulvis water-soluble
- Pharmasin®, Tylovet® 200 solution for injection
- Prazimec-C® tablets for cats
- Prazimec-D® tablets for dogs
- Rodotium®, Vetmulin® 10% solution for injection
- Rodotium®, Vetmulin® 45% water-soluble granules
- Tilmovet®, Biomicosin® 25% oral solution
- Tilmovet®, Biomicosin® 30% solution for injection
- Vialiton solution for injection
- Vitamin C solution for injection
PHARMASIN®/TYLOVET® pulvis
water-soluble
(tylosin)
COMPOSITION
|
Pharmasin/ Tylovet pulvis water-soluble |
|---|---|
Tylosin tartrate, equivalent to tylosin base |
50 g |
Excipients |
up to 100 g |
PHARMACOLOGICAL ACTION
Tylosin is a macrolide antibiotic with a bacteriostatic effect (inhibiting the synthesis of the bacterial proteins) against Gram-positive and some Gram-negative microorganisms, Protozoa and large viruses - Streptococccus spp., Staphylococcus spp., Clostridium spp., Erysipelothrix spp., Pasteurella spp., Campylobacter (Vibrio) spp., Leptospira spp., Brucella spp., Neisseria spp., Ricketsia spp., Actinobacillus (Haemophilus spp., Brachyspira ( Treponema) spp., Serpulina spp.), Borrelia (Spirochaeta spp.), Chlamidia spp., including also some anaerobic microorganisms (Fusobacterium spp., Bacteroides spp.), etc. Of particular importance is the activity of tylosin against Mycoplasma spp. (it excels in efficacy a large number of chemotherapeutic agents). The antimycoplasmal activity of tylosin is potentiated in combination with tetracyclines, with spectinomycin (in concentrations 3 times lower than the respective therapeutic ones – in vitro and in vivo).
Tylosin does not act antimicrobially directly on the bacteria of the family Enterobacteriaceae – E. coli, Salmonella spp., but reveals an antiadhesive activity (hindering their adhesion on the intestinal villi, their penetration through the intestinal mucous membrane and impeding their colonization’s phase as well).
Tylosin proves also an anticoccidial activity mostly against Eimeria tenella. Applied orally, the antibiotic is quickly absorbed and maintains bacteriostatic concentrations in the blood and the target tissues, especially in the lungs, the liver, the kidney for 8-12 h. When given with the drinking water in the recommended dosage schedule, its blood concentrations are over the minimal bacteriostatic ones and are kept during the time of administration. Its absorption is increased in combination with the mucolytic agent bromhexine. Its excretion is mainly through the urine and the bile, the milk (in lactating animals) and the eggs (in egg-producing fowls). Tylosin increases the cellular immunity in chickens. Its influence on T-lymphocytes and B-lymphocytes is relatively short (about 3 days).
Tylosin is compatible with tetracyclines, sulphonamides, erythromycin and spectinomycin. Its solution is sensitive to light (disintegration occurs) and stable to high temperature.
INDICATIONS
For prevention and treatment of infections caused by tylosin-susceptible pathogenic microorganisms – respiratory mycoplasmosis/chronic respiratory disease in chickens and turkeys; infectious synovitis and sinusitis in turkeys; borreliosis (spirochetosis) in fowls and turkeys; necrotic enteritis and infectious coryza in poultry; dysentery and necrotic enteritis in pigs.
CONTRAINDICATIONS
Do not administer to rabbits, guinea pigs and hamsters.
MODE OF ADMINISTRATION (Rp)
The recommended dose of Pharmasin/ Tylovet pulvis water-soluble is necessary to be dissolved in a small quantity of drinking water pouring the water to the preparation (not vice versa). Then the solution thus prepared must be diluted to the desired concentration. The watering troughs must be placed away from direct sunlight.
TARGET SPECIES
Poultry.
DOSAGE
For prevention of fowls - 1.0 g of the preparation (= 0.5 g or 500 000 IU tylosin base) per 1 l of drinking water following the dosage schedule below:
SPECIES |
Age |
Duration of treatment (days) |
|---|---|---|
Chickens for fattening |
1st day |
3 |
Growing commercial layers (Replacement pullets) |
1st day |
3 |
Growing breeder layers |
1st day |
5 |
Turkeys for fattening |
1st day |
5 |
For therapeutic treatment:
Fowls – the same dose of the preparation in the course of 2–5 days depending on the severity of the disease or as per the following scheme: for chickens – 4 days; for pullets – 8 days, for hens – 15 days; for turkeys – 5 days
Pigs – 0.5 g (250 000 IU) per 1-2 l water for 3 to 5 days (the treatment should be carried out at least 24 hours after diarrhea has stopped). Swine which cannot take water or vomit should be treated i.m. with Pharmasin/ Tylovet B-50 or Pharmasin/ Tylovet B-200 after which the treatment should be prolonged with Pharmasin/ Tylovet 10% premix at a dose of 100.0 g/ ton feed (with respect to pure tylosin) in the course of 21 days.
SIDE EFFECTS
In pigs, rarely, erythema, itching of the area around the anus and large intestine prolapse can appear. These signs disappear after the end of the treatment and no special medication is needed.
WITHDRAWAL PERIOD
For meat – 3 days after the last administration of the preparation.
STORAGE
In the original packing, well closed, in dry and well-ventilated facilities, protected from direct sunlight at temperature between 15° and 25°C.
SHELF LIFE
Three (3) years for the product stored in a closed container.
PACKAGING
Plastic bottles of 10, 100 or 200 g; plastic buckets of 1 kg; drums of 25 kg.