PHARMASIN®/TYLOVET® forte

water-soluble for pigs

(tylosin)

COMPOSITION

	Pharmasin/ Tylovet forte water-soluble for pigs
Tylosin tartrate, equivalent to tylosin	20 g
Bromhexine hydrochloride	0.8 g
Excipients	up to 100 g

PHARMACOLOGICAL ACTION

Tylosin is a macrolide antibiotic with a bacteriostatic effect inhibiting the synthesis of bacterial proteins against Gram-positive microorganisms: Staphylococcus spp., Streptococcus spp., Diplococcus spp., Erysipelothrix, Serpulina, Treponema hyodysenteriae, Leptospira spp., Mycoplasma spp., Fusobacterium spp., Bacteroides spp. (anaerobic microorganisms), Campylobacter (Vibrio) coli, Rickettsia spp., Chlamydia spp., and some large viruses. Bromhexine is a mucolytic; it liquefies the bronchial secretion and promotes its ejection from the respiratory tract (by decreasing its viscosity); thus bromhexine elevates the expectoration of the sputum and facilitates the respiration. It stimulates the production of gamma globulin in the bronchial mucosa and helps tylosin to be cumulated in high concentration in the respiratory organ thus hastening the recovery process. In managing pigs suffering from respiratory disease it is applied as an antitussive agent which calms sleep and increases weight gain. Bromhexine influences the absorption rate of tylosin, helps attaining higher blood levels maintaining the bioavailability of the antibiotic. Excretion of tylosin is mainly through urine and bile (the feces respectively), with milk in lactating animals, and also with spermal secretion of the male animals. It is compatible with tetracycline, sulphanilamides, spectinomycin, VAM-F premix (Vitamin- Antibiotic –Mineral Premix), and Biomix premix for pigs.

INDICATIONS

For treatment of enzootic bronchopneumonia complex (with or without secondary bacterial infection), atrophic rhinitis, pharyngitis, tracheobronchitis; campylobacterial (vibrionic) enteritis, swine dysentery; erysipelas, leptospirosis in pigs.

CONTRAINDICATIONS

No contraindications for the medicinal product are established.

MODE OF ADMINISTRATION

Orally, with the drinking water (as a drinking solution only).

The prescribed dose is preliminarily dissolved in a small quantity of water by adding the water to the preparation (not vice versa). Then the mixture is diluted with water until the desired concentration is reached.

TARGET SPECIES

Pigs.

DOSAGE

For prevention of enzootic bronchopneumonia and atrophic rhinitis the product is applied at a concentration of 1.25 g/1 l of drinking water in the course of 10-14 days split into 2 periods of 5-7 days each with an interval of 5-7 days between the periods.

For therapeutic treatment the preparation is administered at the same concentration (1.25 g/1 l of drinking water) in the course of 14 to 21 days without interruption (for quicker absorption into pneumonic areas and for reduction of the hazard for occurrence of persistent infections)

SIDE EFFECTS

In certain cases (rarely), edema in the anus area, rectal prolapse, erythema and skin itching can possibly occur. These signs cease after termination of the application (without additional treatment).

WITHDRAWAL PERIOD

For meat of swine - 3 days after the last administration of the preparation.

STORAGE

In the original packing, well closed, in dry and well-ventilated facilities, protected from direct sunlight at temperature between 15° and 25°C.

SHELF LIFE

Two (2) years from the date of manufacture.

PACKAGING

Plastic bottles of 100 g.