PHARMASIN®/TYLOVET® B-50, B-200

solution for injection

(tylosin base)

COMPOSITION PHARMASIN / TYLOVET B-50

	Pharmasin/ Tylovet B-50 solution for injection
Tylosin	5 g
Excipients	up to 100 ml

COMPOSITION PHARMASIN / TYLOVET B-200

	Pharmasin/ Tylovet B-200 solution for injection
Tylosin	20 g
Excipients	up to 100 ml

PHARMACOLOGICAL ACTION

Tylosin is a macrolide antibiotic with a bacteriostatic effect against Gram-positive and some Gram-negative microorganisms - cocci, Serpulina (Spirochaeta), Vibrio, Leptospira, Mycoplasma, including also some anaerobic microorganisms, etc. Applied intramuscularly, the antibiotic is quickly resorbed reaching maximal concentration in blood thirty minutes after the injection after which it diffuses in tissues, organs, and bodily liquids; it also passes through the blood brain, blood eye, and placental barriers as well as in sexual glands. It exerts a depot action - a single injection maintains the necessary bacteriostatic concentrations for 24 hours. Tylosin is excreted mainly with the urine and bile (with feces respectively), with the milk in lactating animals as well as with sperm liquid in male animals. It is compatible with tetracycline, sulfanilamides, erythromycin and spectinomycin. Its solution is sensitive to light (disintegration occurs).

INDICATIONS

For treatment of respiratory diseases in large and small ruminants, pigs, dogs, cats (rhinitis, tonsillitis, laryngitis, bronchitis, pneumonia, etc.); necrotic enteritis, erythema, enzootic bronchopneumonia, dysentery in pigs; mastitis and endometritis, infectious agalactia in sheep and goats; arthritis of mycoplasmic origin; vibriosis in cows and sheep; panaritium, otitis, and infected wounds; leptospirosis; infectious conjunctivitis in calves and cows.

CONTRAINDICATIONS

The product should not be applied to horses, rabbits, guinea pigs, hamsters as well as to newborn animals.

MODE OF ADMINISTRATION

Intramuscularly! Do not apply more than 10 ml at one injection site.

TARGET SPECIES

Large ruminants, small ruminants, calves, pigs, dogs, cats.

DOSAGE

SPECIES	Tylosin base, ppm	Pharmasin/ Tylovet B-50, ml/ kg b.w.	Pharmasin/ Tylovet B-200, ml/ kg b.w.
Large ruminants	4 – 10	8 – 20/ 100	2 – 5/ 100
Calves	10	10/ 50	2.5/ 50
Small ruminants	12	12/ 50	3/ 50
Pigs	10	2/ 10	2.5/ 50
Dogs	10	2/ 10	2.5/ 50
Cats	10	0.2/ 1

The preparation must be administered once daily for 3 - 5 days.

SIDE EFFECTS

Allergic reactions – erythema, itch, respiratory reactions, slight edema around the anus, prolapse of rectum which could disappear quickly.

WITHDRAWAL PERIOD

For meat and milk - 5 days after the last administration of the preparation.

STORAGE

In the original packing, well closed, in dry and well-ventilated facilities, protected from direct sunlight at temperature between 8° and 15°C.

SHELF LIFE

Three (3) years from the date of manufacture.

PACKAGING

Multidose vials of 50 ml and 100 ml.