PHARMASIN® / TYLOVET® 200

solution for injection

(tylosin tartrate)

COMPOSITION

	Pharmasin/ Tylovet 200 solution for injection
Tylosin tartrate, equivalent to tylosin base	0.2 g
Excipients	up to 1 ml

PHARMACOLOGICAL ACTION

Tylosin is a macrolide antibiotic with a bacteriostatic effect against Gram-positive and some Gram-negative microorganisms - cocci, Corynebacterium, Clostridium, Serpulina (Spirochaeta), Vibrio, Leptospira, Brucella, Neisseria, Haemophilus, large viruses, Chlamydia, including also some anaerobic microorganisms, etc. It is highly effective against Mycoplasma. Applied intramuscularly, the antibiotic is quickly resorbed reaching maximal concentration in blood one hour after the injection. During the first 8 hours blood levels are higher than these reached after treatment with the preparation Pharmasin/ Tylovet B-200 (applied at the same doses). Excretion is mainly through urine and bile (the feces respectively), with milk in lactating animals, and also with sperm in brood animals. It is compatible with tetracycline, sulfanilamides, erythromycin and spectinomycin. Its solution is sensitive to light (disintegration occurs).

INDICATIONS

For treatment of respiratory diseases in large and small ruminants, pigs, dogs (rhinitis, tonsillitis, laryngitis, bronchitis, pneumonia, etc.); necrotic enteritis, erythema, enzootic bronchopneumonia, dysentery in pigs; mastitis and endometritis, infectious agalactia in sheep and goats; arthritis of mycoplasmic origin; vibriosis in cows and sheep; panaritium, otitis, and infected wounds; leptospirosis; infectious conjunctivitis in calves and cows.

CONTRAINDICATIONS

The product must not be applied to horses, rabbits, guinea pigs, hamsters as well as in newly-born animals.

MODE OF ADMINISTRATION (Rp)

Intramuscularly! Do not apply more than 10 ml at one injection site.

TARGET SPECIES

Large ruminants, calves, sheep, goats, pigs, dogs.

DOSAGE

SPECIES	Pharmasin/ Tylovet 200 solution for injection, ml/ kg b.w.
Large ruminants	3.0 – 5.0/ 100 kg b.w.
Calves	2.5/ 50 kg b.w.
Sheep and goats	3.0/ 50 kg b.w.
Pigs	2.5/ 50 kg b.w.
Dogs	0.5 – 2/ 10 kg b.w.

SIDE EFFECTS

Allergic reactions – erythema, itch, respiratory reactions – slight edema, prolapse of rectum, which disappears quickly after some time.

WITHDRAWAL PERIOD

For meat and milk - 5 days after the administration of the preparation.

STORAGE

In the original packing, well closed, in dry and well-ventilated facilities, protected from direct sunlight at temperature between 8° and 15°C.

SHELF LIFE

Eighteen (18) months from the date of manufacture.

PACKAGING

Multidose vials of 50 ml and 100 ml.