PANDEX® 1%

solution for injection

(ivermectin)

COMPOSITION

	Pandex 1% solution for injection
Ivermectin	0.01 g
Excipients	up to 1 ml

PHARMACOLOGICAL ACTION

Ivermectin acts as an endectocide (simultaneously against endo- and ectoparasites). It causes paralysis of the nematodes and the arthropods (insects and acarids) by suppressing the transmission of the nerve impulses in the interneuron synapses of nematodes as well as in the neuromuscular synapses of arthropods. This is realized by stimulation of the release of gammaaminobutyric acid (GABA) from the presynaptic nerve endings which increases its binding to the postsynaptic receptors. In this way the transmission of nervous impulses is interrupted which causes paralysis and death of parasites. Ivermectin is well tolerated by mammals (because in them GABA is localized only in the central nervous system and ivermectin cannot pass through the blood-brain barrier).

Ivermectin affects both nematode adult forms and larvae (fourth stage) of inhibited lung helminths as well as Hypoderma migratory larvae. Ivermectin does not induce teratogenic and embryotoxic effect. It is well tolerated by pregnant animals. It does not affect the reproduction functions of male brood animals.

INDICATIONS

In large ruminants - gastrointestinal and pulmonary nematodiasis (ostertagiasis, hemonchosis, trichostrongylosis, cooperiasis, parafilariasis, oesophagostomosis , bunostomiasis , nematodiriasis, dictyocaulosis); eye nematodiasis (thelaziasis); invasion with insects and acars (lice, pasture ticks); psoroptic and sarcoptic mange; hypodermiasis. In small ruminants - gastrointestinal and pulmonary nematodiasis (ostertagiasis, hemonchosis, trichostrongylosis, cooperiasis, oesophagostomosis, nematodiriasis, strongyloidiasis, chabertiosis, trichuriasis, gaigeriasis, dictyocaulosis); invasions with insects and acars (lice, Melophagus spp., pasture ticks, mange mites, psoroptic and chorioptic mites); oestrosis.

In pigs - nematodiasis (ascariasis, strongyloidiasis, hyostrongylosis , metastrongyloidosis , oesophagostomosis); invasions with lice; sarcoptic mange.

CONTRAINDICATIONS

The product must not be applied to dogs of breeds Collie, Shelti, and Bobtail as well as to tortoises.

MODE OF ADMINISTRATION (Rp)

Subcutaneously. Do not apply intramuscularly or intravenously!

TARGET SPECIES

Ruminants, pigs.

DOSAGE

Large ruminants - 200 µg/ kg b.w. of the substance.

Body weight (kg)	50	100	150	200	250	300	350	400	450	500	550	600
Dose volume of the preparation (ml)	1.0	2.0	3.0	4.0	5.0	6.0	7.0	8.0	9.0	10.0	11.0	12.0

Small ruminants - 200 µg/ kg b.w. of the substance.

Body weight (kg)	25	50	75
Dose volume of the preparation (ml)	0.5	1.0	1.5

In case of scab – 2 injections with a 7 day interval.

Pigs - 300 µg/kg b.w. of the substance.

Body weight (kg)	16	33	66	100	133	166	200
Dose volume of the preparation (ml)	0.5	1.0	2.0	3.0	4.0	5.0	6.0

SIDE EFFECTS

Not established.

WITHDRAWAL PERIOD

For meat - 14 days after the last administration of the preparation. For milk - 28 days after the last administration of the preparation.

SHELF LIFE

Three (3) years from the date of manufacture.

STORAGE

In the original packing, well closed, in dry and well-ventilated facilities, protected from direct sunlight at temperature between 8° and 15°C.

PACKAGING

Multidose vials of 25, 50 and 100 ml.

WARNING

Keep out of the reach of children!