OXYTETRACYCLINE 10%

solution for injection

(oxytetracycline)

COMPOSITION

	Oxytetracycline 10% solution for injection
Oxytetracycline hydrochloride, equivalent to oxytetracycline base	0.1 g
Excipients	up to 1 ml

PHARMACOLOGICAL ACTION

Oxytetracycline is a bacteriostatic antibiotic with a wide spectrum of activity against Gram-positive (Cocci, Corynebacterium, Clostridia, Erysipelothrix, Actinomycetes, etc.) and Gram-negative (Escherichia coli, Salmonella, Pasteurella, Haemophilus, Brucella, Pseudomonas, Bordetella, etc.) microorganisms, Mycoplasmas, Chlamydiae, Rrickettsiae, some protozoa (Anaplasma, Leptospires, Spirochetes, etc.) and large viruses. It is absorbed from the injection site and penetrates into all the body organs, tissues and fluids, the placental barrier included. It is excreted in an active form in urine, bile, feces and milk.

INDICATIONS

In infections of the respiratory and urogenital tracts, gastrointestinal canal, and the soft tissues; in septic conditions; in secondary bacterial infections, in viral diseases caused by oxytetracycline-sensitive pathogenic microorganisms (colibacillosis, salmonellosis, pasteurellosis, leptospirosis, listeriosis, bronchopneumonia, actinobacillosis, anaplasmosis, swine erysipelas); in mastitis-metritis-agalactia (MMA) syndrome in sows; in metritis, mastitis, post-operative conditions, enterotoxemia, pyelonephritis, tetanus, foot rot, malignant edema, infectious polyarthritis, spirochetosis, etc. in large and small ruminants, horses, pigs, dogs, cats, fur-bearing animals (fox, mink), and birds.

CONTRAINDICATIONS

Animals with kidney impairment; pregnant animals; newborn animals.

Do not apply to young animals during the period of tooth development (it may lead to brown coloration of teeth). Do not administer intravenously to horses, dogs and cats.

It is not advisable to be used simultaneously with chemotherapeutics with bactericidal activity.

MODE OF ADMINISTRATION (Rp)

Intramuscularly, subcutaneously, and slowly intravenously.

The dose on a single site in intramuscular administration must not exceed 10 ml for large ruminants, 5 ml for pigs, 3-5 ml for sheep and goats and 1 ml for small animals. Before use warm up the solution to body temperature.

TARGET SPECIES

Ruminants, sheep, goats, pigs, dogs, cats, fowls, minks, foxes.

DOSAGE

SPECIES	Oxytetracycline 10% solution for injection, ml/ kg b.w.
Large ruminants and horses	3 – 5 ml/ 50 kg b.w. (in anaplasmosis – 10 ml/ 100 kg b.w.)
Sheep and goats	2 – 3 ml/ 50 kg b.w.
Pigs	0.5 – 1 ml/ 10 kg b.w.
Dogs	1 ml/ 10 kg b.w
Cats	0.1 ml/ kg b.w.
Fowls	0.3 – 0.5 ml/ kg b.w.
Minks and foxes	2 ml/ 10 kg b.w.

The higher doses of each dosage scale are intended for the younger animals of the respective species.

The preparation must be applied once daily for 3-5 days.

SIDE EFFECTS

Not established.

WITHDRAWAL PERIOD

For meat - 10 days after the last administration of the preparation. For milk - 3 days after the last administration of the preparation.

STORAGE

In the original packing, well closed, in dry and well-ventilated facilities, protected from direct sunlight at temperature between 15° and 25°C. Do not freeze! Protect from frost!

SHELF LIFE

Two (2) years from the date of manufacture.

PACKAGING

Multidose vials of 100 ml.