GENTAMICIN 4%

solution for injection

(gentamicin sulphate)

COMPOSITION

	Gentamicin 4% solution for injection
Gentamicin sulphate, equivalent to gentamicin base	0.04 g
Excipients	up to 1 ml

PHARMACOLOGICAL ACTION

Gentamicin is an aminoglycoside antibiotic with a bacteriocidal static effect mainly against Gram-negative and some Gram-positive microorganisms (Escherichia coli, Salmonella spp., Klebsiella spp., Shigella spp., a number of Proteus and Pseudomonas strains, Staphylococci, beta-hemolytic Streptococci, Corynebacteria, Mycoplasma, etc.). It is quickly absorbed from the injection site and is retained in the blood and tissues for 12 – 24 h. It is eliminated unchanged in the urine, where its concentrations significantly exceed those in the blood.

INDICATIONS

For treatment of respiratory, gastrointestinal and urogenital infections (bronchitis, pneumonia, pyelonephritis, cystitis, urethritis, endometritis, colibacillosis, salmonellosis, infected wounds, pyodermia sepsis, etc.), caused by gentamicin-sensitive microorganisms.

CONTRAINDICATIONS

In cases of continuous administration in higher doses the preparation may cause heavy nephritis and damages of the vestibular and hearing organs, especially in cats. If ataxia and vomiting occur, the treatment must be terminated.

MODE OF ADMINISTRATION (Rp)

Intramuscularly, subcutaneously, orally and intrauterinally.

TARGET SPECIES

Ruminants, horses, pigs, dogs, cats.

DOSAGE

Intramuscularly

SPECIES	Gentamicin 4% solution for injection, mg/ kg b.w.	Gentamicin 4% solution for injection, ml/ 100 kg b.w.
Ruminants, horses	2 – 4	5 – 10
Pigs	5	12.5
Dogs and cats	4 – 6	1.0 – 1.5

On the first day, the dose must be injected twice at a 12-hour interval. Subsequently, Gentamicin 4% is administered once per day for not more than 7 consecutive days.

Subcutaneously

In chickens (for control of colibacillosis and paratyphus) the preparation is diluted with sterile distilled water (1:40) and is injected at a dose rate of 0.2 ml/1-day-old chicken.

Orally, with the drinking water

In chickens of older age - 2.5 ml/ l drinking water in the course of 4-5 days.

Intrauterinally

In cows (for treatment of endometritis) - 5.0 ml of the preparation diluted with 20-50 ml isotonic solution of sodium chloride.

In mares - 12.5 ml of the preparation diluted with 200 ml isotonic solution of sodium chloride. In case - of pyometra the exudate must be preliminarily removed.

SIDE EFFECTS

Severe renal disorders accompanied by azotemia.

Do not apply simultaneously with general anesthetics, muscle relaxants, other aminoglycosides,polymyxins.

WITHDRAWAL PERIOD

For meat (excluding kidneys and injection site) - 7 days after the last administration of the preparation. For kidneys and injection site - 45 days after the last administration of the preparation. For milk - 2 days after the last administration of the preparation.

SHELF LIFE

Two (2) years from the date of manufacture.

STORAGE

In the original packing, well closed, in dry and well-ventilated facilities, protected from direct sunlight at temperature between 8° and 15°C.

PACKAGING

Multidose vials of 50 ml.