TILMOVET® 4%, 9%, 10%, 14%, 20% PREMIX

BIOMICOSIN® 4%, 9%, 10%, 14%, 20% PREMIX

(tilmicosin phosphate)

COMPOSITION

	Tilmovet 4% premix	Tilmovet 9% premix	Tilmovet 10% premix	Tilmovet 14% premix	Tilmovet 20% premix
Tilmicosin (as tilmicosin phosphate)	4 g	9 g	10 g	14 g	20 g
Excipients	up to 100 g	up to 100 g	up to 100 g	up to 100 g	up to 100 g

PHARMACOLOGICAL ACTION

Tilmicosin, 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)-desmycosin is chemically modified long-acting macrolide antibiotic applied in the veterinary medicine. It is active mainly against Gram-positive and some Gram-negative microorganisms (Streptococci, Staphylococci, Pasteurella spp., mycoplasmas, etc.). Applied orally in pigs, tilmicosin reaches maximum blood levels after 2 hours and maintains high therapeutic concentrations in the target tissues. It is concentrated in the lungs, penetrating intracellularly in the alveolar macrophages. It is eliminated mainly through feces and urine. Tilmicosin induces no teratogenic and embryotoxic effect.

INDICATIONS

For prophylactics (metaphylactics) and treatment of bacterial respiratory diseases caused by Mycoplasma hyopneumoniae (enzootic pneumonia); Actonobacillus pleuropneumoniae (actinobacillus pleuropneumonia); Haemophilus parasuis (Haemophilus pneumonia or Glasser’s disease); Pasteurella multocida (pasteurellosis); Bordetella bronchiseptica and other microorganisms sensitive to tilmicosin.

Secondary bacterial infections associated with porcine reproductive and respiratory syndrome (PRRS) and circovirus pneumonia (post-weaning multisystemic wasting syndrome - PMWS and porcine dermatitis and nephropathy syndrome – PDNS).

Bacterial infections of the alimentary tract caused by Brachispira hyodysenteriae (classic dysentery); Lawsonia intracellularis (proliferative and hemorrhagic ileitis); Brachispira pilosicoli (colon spirochetosis); Staphylococcus spp. and Streptococcus spp.; in stress conditions for prevention (metaphylactics) after weaning, moving, regrouping and transportation of pigs.

CONTRAINDICATIONS

Not established.

MODE OF ADMINISTRATION

Orally, well homogenized into feed.

In order to reach uniform homogenization with feed, it is recommended to mix the measured quantity of the preparation (calculated on the basis of the prescribed dose) on stages in the following order: up to 10 kg feed; up to 100 kg feed; and up to 1000 kg feed.

TARGET SPECIES

Pigs.

DOSAGE

	Tilmicosin ppm	Tilmovet 4% premix kg/t feed	Tilmovet 10% premix kg/t feed	Tilmovet 20% premix kg/t feed
Prevention/ Control(for the risk period, typically for 21 days, recommended to start 7 days prior to an expected disease outbreak)	200	5	2	1
Treatment(for a period of 10-15 days)	200-400	5-10	2-4	1-2

SIDE EFFECTS

Not established.

WITHDRAWAL PERIOD

For meat - 14 days after the last administration.

STORAGE

In the original packing, well closed, in dry and well-ventilated facilities protected from direct sunlight at temperature between 15° and 25°C..

SHELF LIFE

Two (2) years from the date of manufacture.

PACKAGING

Polyethylene bags and secondary paper bags of 10 kg and 25 kg, polypropylene/ aluminum/ polyethylene sachets of 20 g, 100 g, 500 g or 1000 g.

WARNING

People handling the product must wear personal protective devices such as anti-dust mask (respirator) or local respiration system, protective gloves of impermeable rubber and safety goggles and/or face shield. Do not eat or smoke in the area of material storage. Wash the hands with soap before eating or smoking.