RODOTIUM® 80% granulated/coated PREMIX

VETMULIN® 80% granulated/coated PREMIX

(tiamulin hydrogen fumarate)

COMPOSITION

	Rodotium/Vetmulin 80% granulated/ coated premix
Tiamulin hydrogen fumarate	80 g
Excipients	up 100 g

PHARMACOLOGICAL ACTION

Rodotium/ Vetmulin 80% granulated/ coated premix contains tiamulin hydrogen fumarate, a semi-synthetic antibiotic of the diterpene group. Tiamulin is active against mycoplasmas, Haemophilus parasuis (Glasser disease), Brachispira hyodysenteriae, Lawsonia intracellularis (ileitis), Serpulina pilosicoli (spirochetosis of the colon), Gram-positive microorganisms. It does not affect directly E. coli, but it exhibits antiadhesive effect, which facilitates the action of the other antibiotics.

INDICATIONS

For prevention (metaphylaxis) and treatment of enzootic bronchopneumonia, actinobacillus pleuropneumonia, chronic respiratory disease, dysentery (bloody diarrhea), proliferative enteropathy (ileitis) and spirochetosis of the colon; in cases of increased morbidity and mortality rate of unknown etiology; for overcoming of stress conditions (such as transfer into another box or long transportation); for suppression of secondary bacterial infections in Porcine Reproductive and Respiratory Syndrome (PRRS) in pigs and other virus infections.

CONTRAINDICATIONS

Not established.

MODE OF ADMINISTRATION

Orally, well homogenized into feed.

A preliminary dilution to 10% premix (1 kg Rodotium/ Vetmulin 80% granulated/ coated premix + 7 kg feed) is recommended, and then the prescribed quantity of the product (based on the dose indicated) is mixed with the complete feed.

TARGET SPECIES

Pigs.

DOSAGE

Pigs

INDICATIONS	Prevention/Control			Treatment
	Tiamulin ppm	Rodotium 80% premix g/ ton feed	Duration of treatment (weeks)	Tiamulin ppm	Rodotium 80% Duration of premix         treatment g/ ton feed        (days)
Enzootic pneumonia	80	100	4 – 6	200/ 40	250/50	10/ 6 weeks
Pleuropneumonia	80	100	4 – 6	200	250	10
Chronic respiratory disease	80	100	4 – 6	200	250	10
Dysentery	40	50	4 – 6	100 – 120	125 – 150	3 – 5
Ileitis	40	50	4 – 6
Spirochetosis of the colon	40	50	4 – 6
Stress conditions Secondary bacterial infections in PRRSVirus infections	100	125	10 days
Increased morbidity and mortality rate	40	50	6 – 8

Poultry

SPECIES	Prevention/Control			Treatment
	Tiamulin ppm	Rodotium 80% premix g/ ton feed	Duration of treatment (weeks)	Tiamulin ppm	Rodotium 80% premix g/ ton feed	Duration of treatment (days)
Chickens for fattening	200 400	250 500	Day-1st, 2d, 3rd Week 4th, day 1st	400	500	3 – 5
Breeder layers, replacement pullets	200	250	Day-1st, 2d, 3rd	400	500	3 – 5
	400	500	Week 4th, day 1 Week 9th, day 1 Week 16th, day 1

SIDE EFFECTS

Not established.

WITHDRAWAL PERIOD

3 - 5 days after the last administration of the preparation depending on the dose.

STORAGE

In the original packing, well closed, in dry and well-ventilated facilities, protected from direct sunlight at temperature between 15° and 25°C.

SHELF LIFE

Two (2) years after the first opening of the container.

PACKAGING

Sachets of 125 g or 1 kg, plastic buckets of 1 kg; drums of 5 kg, 10 kg and 25 kg.

MEDICINAL INTERACTIONS

Tiamulin is incompatible with ionophore antibiotics hence animals must not receive products containing monensin, salinomycin, or narasin during or for at least seven days before or after treatment with Rodotium/ Vetmulin 80% granulated/ coated premix.