POULCOX® 10%, 20%, 40% PREMIX

BOBIOVET® 10%, 20%, 40% PREMIX

(monensin sodium)

COMPOSITION

	Poulcox/ Bobiovet 10% premix	Poulcox/ Bobiovet 20% premix	Poulcox/ Bobiovet 40% premix
Monensin sodium	10 g	20 g	40 g
Excipients	up to 100 g	up to 100 g	up to 100 g

PHARMACOLOGICAL ACTION

Monensin is a polyether antibiotic of the ionophore group. It exerts an anticoccidial action against Eimeria tenella, E. acervulina, E. mivati, E. brunetti, E. maxima, E. necatrix in chickens, affecting the trophozoites in the first stage of schizogony. Its action is connected with the formation of lipophilic complexes with monovalent ions (sodium and potassium), making the membranes of the coccidial cells permeable to the ions mentioned; hence the active sodium and potassium transport is disturbed. Sodium and chloride are accumulated into the cells of the parasites, drawing water into the sporosoites, causing their swelling and rupture. It hinders the maturing of the schizonts and the development of merozoites. An additional influence is the impeded transport of carbohydrate and the active sporozoite glycolysis provoked by monensin. Applied at the recommended dosage levels in fowls, monensin is practically not absorbed by the gastrointestinal tract and is not deposited in muscles and internal organs. Nevertheless, a withdrawal period of 3 days is recommended for slaughter of treated chickens for human consumption. The therapeutic range of the antibiotic is narrow; therefore it must be applied at the accurate dosage levels and for the appropriate use. More susceptible poultry species are guinea hens, turkeys (above 16 week of age) and swimming fowls.

When orally administered to ruminants (with developed forestomachs), monensin modifies ruminal metabolism, directing it predominantly to the formation of the energetically richer propionic acid (at the expense of the other volatile fatty acids - acetic acid, lactic acid), and to inhibition of protein degradation in the rumen as a result of which feed conversion efficiency is improved and the weight gain is increased. Monensin suppresses also the formation of methane genesis of the ruminants and inhibits its eructation out of the forestomachs which spares energy losses. The therapeutic range of the antibiotic is narrow; therefore it must be applied at the accurate dosage levels and for the appropriate use. Horses and donkeys are extremely susceptible to monensin.

INDICATIONS

For prevention of coccidiosis in chickens for fattening and chickens reared for laying up to 16 weeks of age, caused by Eimeria tenella, E. acervulina, E. Mivati, E. brunetti, E. maxima, E. necatrix. For prevention of coccidiosis in turkeys (up to 16 weeks of age) caused by Eimeria adenoides, Eimeria meleagrimitis and Eimeria gallopavonis. For stimulation of weight gain rate and improvement of feed conversion efficiency in pigs (up to three months of age). For stimulation of weight gain rate and improvement of feed conversion efficiency in ruminants with developed forestomachs (lambs and weaned lambs). For prevention of ketosis in dairy cows.

CONTRAINDICATIONS

Feed containing monensin and intended for chickens must not be given to laying hens, turkeys (over 16 weeks), swimming fowls, guinea hens and some other species - especially horses and donkeys. Monensin is incompatible with tiamulin, erythromycin, oleandomycin, sulphamezathine (sulphadimidine), sulphadimethoxine, sulphaquinoxaline.

MODE OF ADMINISTRATION

Orally, thoroughly mixed into feed.

In order to reach uniform homogenization with feed, it is recommended to mix the measured quantity of the preparation (calculated on the basis of the prescribed dose) on stages in the following order: up to 10 kg feed; up to 100 kg feed; and up to 1000 kg feed.

TARGET SPECIES

Chickens and turkeys, lambs, beef cattle, dairy cows, pigs.

DOSAGE

Fowls

SPECIES	Monensin sodium ppm	Poulcox 10 % premix g/ ton feed	Poulcox 20% premix g/ ton feed	Poulcox 40% premix g/ ton feed	Duration of treatment
Chickens for fattening	90 – 110	900 – 1100	450 – 550	225 – 275	The entire rearing period
Chickens reared for laying (up to 16 weeks of age)	90 – 110	900 – 1100	450 – 550	225 – 275	Up to 16 weeks of age
Turkeys (up to 16 weeks of age)	54 – 90	540 – 900	270 – 450	135 – 225	Up to 16 weeks of age
Pigs
SPECIES	Monensin sodium ppm	Poulcox 10 % premix g/ ton feed	Poulcox 20% premix g/ ton feed	Poulcox 40% premix g/ ton feed	Duration of treatment
Pigs up to 3 to 4 months of age	50	500	250	125	3 – 4 months

Ruminants

SPECIES	Monensin sodium ppm	Poulcox 10 % premix g/ton feed	Poulcox 20% premix g/ton feed	Poulcox 40% premix g/ton feed	Duration of treatment
Lambs fattened with concentrated feed at a full ration mixture	10	100	50	25	The entire rearing period
Lambs fattened with concentrated feed and hay	10	100/ 200	50/ 100	25/ 50	During 1st fattening period (40-50) days / During 2d fattening period
Weaned lambs	10	100/ 200	50/ 100	25/ 50	During 1st 30 days
Cows (with subclinical signs of ketosis)	2.5 g of Poulcox/ Bobiovet 10% per cow daily, 1.25 g of Poulcox/ Bobiovet 20% per cow daily or 0.625g. of Poulcox/ Bobiovet 40% per caw daily (divided into two equal parts administered in the morning and in the evening) from the 12th to the 15th day prior to calving.				35 days

SIDE EFFECTS

In case of overdosage, possible suppression of growth and intoxication (expressed in loss of appetite, tremor, paresis of limbs and death) could occur.

WITHDRAWAL PERIOD

For meat:

Chickens and turkeys - 3 days after the last administration of the preparation.

Pigs - 1 day after the last administration of the preparation.

Lambs and weaned lambs - 2 days after the last administration of the preparation.

STORAGE

In the original packing, well closed, in dry and well-ventilated facilities, protected from direct sunlight at temperature between 15° and 25°C.

SHELF LIFE

Two (2) years from the date of manufacture.

PACKAGING

25 kg PE-lined multi-layer paper bags.

WARNING

Do not leave or dispose of medicated feed or premix containing monensin in places accessible to other domestic or wild animal species.

REGION:

Products