SACOX® 120 microGranulate

(salinomycin sodium)

COMPOSITION

	Sacox 120 microGranulate
Salinomycin sodium	120 g
Excipients	up to 1 kg

PHARMACOLOGICAL ACTION

The biological activity of Sacox is due to its ability to form complexes with cations, particularly its ability to transport potassium ions into and out of the cell. The salinomycin molecule encloses the cation in a hallow-ball configuration, immobilizing the central ion with secondary valence bonds. Outside the complex there are largely neutral, lipophilic hydrocarbon groups, which give the complex the ability to penetrate into the living cells. Because of the loose complex formulation with the cation, salinomycin can function as an ion carrier and can transport cations, particularly potassium, ions, into and out of the cell. The resulting disturbance in the parasite’s intercellular ion concentration explains the coccidiocidal activity. During asexual development of the coccidia, Sacox has a coccidiocidal effect on sporozoties and merozoties. Subsequent development of schizonts is also severely impaired; thus, the damage to the intestine is reduced to an absolute minimum.

INDICATIONS

For the prophylactic control of the coccidial species E. acervulina, E. maxima, E. necatrix, E. mivati, E. tenella and E. brunetti affecting chickens for fattening and chickens reared for laying. It is also applied for prevention of coccidiosis in rabbits for fattening caused by E. coecicola, E. perforans, E. media, E. irresidua, E. magna, E. piriformis, E. intestinalis, E. flavescens, E. stiedai.

CONTRAINDICATIONS

Equines must not be allowed to gain access to feed containing salinomycin; ingestion of salinomycin by equines has proved fatal. Not to be used in feeds containing any other anticoccidial.

MODE OF ADMINISTRATION

Orally, well homogenized into feed.

In order to reach uniform homogenization with feed, it is recommended to mix the measured quantity of the preparation (calculated on the basis of the prescribed dose) on stages in the following order: up to 10 kg feed; up to 100 kg feed; and up to 1000 kg complete feed.)

TARGET SPECIES

Chickens for fattening, chickens reared for laying and rabbits for fattening.

DOSAGE

SPECIES	Salinomycin sodium ppm	Sacox 120 microGranulate g/ton feed	Max. age
Chickens for fattening	60 – 70	500 – 583	-
Chickens reared for laying	50	417	12 weeks
Rabbits for fattening	20 – 25	167 – 208	-

SIDE EFFECTS

None under correct use of the product.

WITHDRAWAL PERIOD

One (1) day.

STORAGE

In the original packing, well closed, in dry and well-ventilated facilities, protected from direct sunlight at temperature between 15° and 25°C.

SHELF LIFE

Two (2) years from the date of manufacture.

PACKAGING

25 kg PE-lined multi-layer paper bags, 750 kg bags.

WARNING

Animals must not be treated with products containing tiamulin in high dosage while receiving or for at least seven days before or after receiving feed containing Sacox 120 microGranulate.