COXIDIN® 200 microGranulate

(monensin sodium)

COMPOSITION

	Coxidin 200 microGranulate
Monensin sodium	200 g
Excipients	1 kg

PHARMACOLOGICAL ACTION

Monensin is a polyether antibiotic of the ionophore group. It exerts an anticoccidial action against Eimeria tenella, E. acervulina, E. mivati, E. brunetti, E. maxima, E. necatrix in chickens, affecting the trophozoites in the first stage of schizogony. Its action is connected with the formation of lipophilic complexes with monovalent ions (sodium and potassium), making the membranes of the coccidial cells permeable to the ions mentioned; hence the active sodium and potassium transport is disturbed. Sodium and chloride are accumulated into the cells of the parasites, drawing water into the sporosoites, causing their swelling and rupture. It hinders the maturing of the schizonts and the development of merozoites. An additional influence is the impeded transport of carbohydrate and the active sporozoite glycolysis provoked by monensin. Applied at the recommended dosage levels in fowls, monensin is practically not absorbed by the gastrointestinal tract and is not deposited in muscles and internal organs. Nevertheless, a withdrawal period of 1 day is recommended for slaughter of treated chickens for human consumption. The therapeutic range of the antibiotic is narrow; therefore it must be applied at the accurate dosage levels and for the appropriate use. More susceptible poultry species are guinea hens, turkeys (above 16 week of age) and swimming fowls. Horses and donkeys are extremely susceptible to monensin.

INDICATIONS

For prevention of coccidiosis in chickens for fattening caused by Eimeria tenella, Eimeria acervulina, Eimeria mivati, Eimeria brunetti, Eimeria maxima, Eimeria necatrix, and in turkeys for fattening caused by Eimeria gallopavonis, Eimeria meleagrimitis, Eimeria adenoides and Eimeria dispersa.

CONTRAINDICATIONS

Coxidin 200 is dangerous for equines. Feed containing monensin and intended for chickens and turkeys for fattening must not be given to laying hens, turkeys (over 16 weeks of age), swimming fowls, guinea hens. This feedingstuff contains an ionophore: avoid simultaneous administration with tiamulin and monitor for possible adverse reactions when used concurrently with other medicinal substances.

MODE OF ADMINISTRATION

Orally, thoroughly mixed into feed.

In order to reach uniform homogenization with feed, it is recommended to mix the measured quantity of Coxidin200 (calculated on the basis of the prescribed dose) on stages in the following order: up to 10 kg feed; up to 100 kg feed; and up to 1000 kg feed.

TARGET SPECIES

Chickens for fattening and turkeys for fattening.

DOSAGE

SPECIES	Monensin sodium ppm	Coxidin 200 microGranulate g/ ton feed
Chickens for fattening	100 – 125	500 – 625
Turkeys for fattening	60 – 100	300 – 500

SIDE EFFECTS

In case of overdosage, possible suppression of growth and intoxication (expressed of loss of appetite, tremor, paresis of limbs and death) could occur.

WITHDRAWAL PERIOD

One (1) day after the last administration of the additive in chickens for fattening.

One (1) days after the last administration of the additive in turkeys for fattening.

STORAGE

In the original packing, well closed, in dry and well-ventilated facilities, protected from direct sunlight at temperature between 15° and 25°C.

SHELF LIFE

Two (2) years from the date of manufacture.

PACKAGING

25 kg PE-lined multi-layer paper bags.

WARNING

Harmful by inhalation and if swallowed. Irritating to eyes. When using do not eat, drink or smoke. Do not breathe dust. Avoid contact with eyes. In case of contact with eyes wash with plenty of water. Wear suitable protective clothing, gloves and eye/ face protection. In case of insufficient ventilation, wear suitable respiratory equipment. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).